The greatest difficulties in managing a patient with numerous actinic keratoses is deciding the order in which to treat the specific lesions and what modality to use. The patient with a small number of lesions is probably most conveniently and cost effectively treated using destructive techniques like cryosurgery, electrodesiccation or photodynamic therapy with lasers. However, patients with large numbers of lesions are probably best managed using a topical chemotherapy agent, like 5-florouracil or imiquimod. If the patient’s health insurance company limits coverage for the treatment of a specific number AK’s per visit, it may be most prudent and logical to begin treatment of the largest or most rapidly growing AK’s first and continue treatment of remaining lesions at subsequent visits until all lesions have been eradicated.

Semin Cutan Med Surg 24:152-154 © 2005 Elsevier Inc. All rights reserved.

This article will attempt to summarize the most important of the issues that may represent potential pitfalls for the physician.