PRECISION MEDICINE
Precision medicine and precision therapeutics: Hedgehog signaling pathway, basal cell carcinoma and beyond
Jun
2014
Vol. 33. No. 2
Precision medicine and precision therapeutics is currently
in its infancy with tremendous potential to improve patient
care by better identifying individuals at risk for skin cancer
and predict tumor responses to treatment. This review
focuses on the Hedgehog signaling pathway, its critical
role in the pathogenesis of basal cell carcinoma, and the
emergence of targeted treatments for advanced basal
cell carcinoma. Opportunities to utilize precision medicine
are outlined, such as molecular profiling to predict
basal cell carcinoma response to targeted therapy and to
inform therapeutic decisions.
Semin Cutan Med Surg 33:68-71 © 2014 Frontline Medical
Communications
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