Epidemiological studies of severe drug hypersensitivities
are important to understanding the morbidity and
mortality of this heterogeneous group of disorders. These
insights also allow greater identification of at-risk patient
groups. However, epidemiological studies of drug hypersensitivity
reactions are challenging due to the variable
diagnostic criteria applied and incomplete data sets
studied. We review the epidemiology of severe drug hypersensitivity
reactions with a particular focus on severe
cutaneous adverse reactions (SCARs). SCAR diseases
include: Stevens-Johnson syndrome, toxic epidermal
necrolysis, drug rash eosinophilia and systemic symptoms,
serum-sickness–like reaction and acute generalized
Among the more than 3,000 skin conditions that dermatologists manage, there are a number of severe, acute cutaneous diagnoses which either warrant hospitalization on their own or can arise in the inpatient setting and demand skilled inpatient dermatological consultation.
We have highlighted new information regarding syndromes with cutaneous manifestations and present several newly described dermatologic diagnoses.
Bullous skin diseases are characterized by the presence of blisters and/or erosions of the skin and mucous membranes.
The variety of causes of generalized blistering includes autoimmune, drug-induced, neoplastic, and infectious etiologies.