A topic dermatitis is a chronic relapsing condition that can have a substantial impact on quality of life.
Several immunologic mediators—phosphodiesterase (PDE), interleukin (IL), small molecules, and Janus kinase—have been implicated in the pathogenesis of atopic dermatitis, and evidence has shown that blocking these mediators can help modify the disease process.
Eichenfield LF, Stein Gold LF. Addressing the immunopathogenesis of atopic dermatitis: advances in topical and systemic treatment. Sem Cutan Med Surg. 2017;36(Suppl 2):S45-S48. https://doi.org/10.12788/j.sder.2017.012.
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