Jeremy B. Green

Guest Editor for the following articles:

Sep
2011
Vol. 30. No. 3

Innovative Cosmeceuticals: Sirtuin Activators and Anti-Glycation Compounds

Patricia K. Farris, MD
Skin aging is a combination of natural aging with superimposed photoaging. Naturally aged skin is thin, fragile and finely wrinkled whereas photoaged skin is rough and thickened with deep coarse wrinkles. In addition photoaging is characterized by mottled pigmentation, solar lentigines, telangectasias and a loss of elasticity. The science behind skin aging has exploded in the past decade. Skin aging has now been defined on both a cellular and molecular level. The study of genomics in aging skin provides us with potential targets as points for intervention. In this regard, the science behind skin aging becomes a platform for the development of new anti-aging strategies and products. In this paper two new and emerging approaches to treat aging skin will be discussed. Sirtuin activating and antiglycation products are already being marketed by cosmetic and pharmaceutical companies. These anti-aging approaches are backed by basic science research and the ingredients used are supported by proof of concept studies although clinical trials are often lacking. It is this bench to beauty counter approach to cosmeceuticals that remains an industry standard today. Semin Cutan Med Surg 30:163-166 © 2011 Elsevier Inc. All rights reserved.
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Sep
2015
Vol. 34. No. 3

Therapeutic approaches to cellulite

Andrei I Metelitsa, MD, FRCPC | Jeremy B Green, MD | Joel L. Cohen, MD | Joely Kaufman, MD | Michael E. Kaminer, MD

Cellulite is a condition that affects the vast majority of women. Although it is of no danger to one’s overall health, cellulite can be psychosocially debilitating. Consequently, much research has been devoted to understanding cellulite and its etiopathogenesis. With additional insights into the underlying causes of its clinical presentation, therapeutic modalities have been developed that offer hope to cellulite sufferers. This review examines evidence for topical treatments, noninvasive energy-based devices, and recently developed minimally invasive interventions that may finally provide a solution.
Semin Cutan Med Surg 34:140-143 © 2015 Frontline Medical Communications

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Sep
2015
Vol. 34. No. 3

Cellfina observations: pearls and pitfalls

Jeremy B Green, MD | Joel L. Cohen, MD

In our experience, patients tend to consider any undesirable feature on their body from the knees to the umbilicus, and even the arms, to be cellulite. It is important to educate prospective patients that Cellfina (Ulthera, Inc, Mesa, Arizona) most effectively treats dimple-type cellulite, whereby fibrous bands inserting into the undersurface of the skin cause a puckered appearance. In this brief communication, we would like to share our experience in optimizing outcomes with Cellfina for the treatment of cellulite.
Semin Cutan Med Surg 34:144-146 © 2015 Frontline Medical Communications

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Sep
2011
Vol. 30. No. 3

Cosmeceuticals for Cellulite

Doris Hexsel, MD
Cellulite is characterized by alterations to the skin surface, presenting as dimpled or puckered skin of the buttocks and posterior and lateral thighs. It mainly affects women. Cellulite occurrence is believed to be due to structural, inflammatory, morphological and biochemical alterations of the subcutaneous tissue. However, its pathogenesis is not completely understood. Topical treatments for cellulite include many agents, such those that increase the microcirculation flow, agents that reduce lipogenesis and promote lipolysis, agents that restore the normal structure of dermis and subcutaneous tissue, and agents that scavenge free radicals or prevent their formation. There are many cosmetic and medical treatments for cellulite. However, there is little clinical evidence of an improvement in cellulite, and none have been shown to lead to its resolution. The successful treatment of cellulite will ultimately depend upon our understanding of the physiopathology of cellulite adipose tissue. Semin Cutan Med Surg 30:167-170 © 2011 Elsevier Inc. All rights reserved.
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Sep
2015
Vol. 34. No. 3

Hand rejuvenation

David Ozog, MD | Farhad R Riyaz, MD

Aging of the hands results from both natural processes and chronic ultraviolet light exposure. Together, these cause textural and pigmentary changes, excess skin laxity, rhytides, and soft tissue atrophy that presents as prominent bones and tendons with easily visible veins. Many options are available for the reversal of these changes. Photoaging can be improved with chemical peels and light-based treatments (such as Q-switched lasers), resurfacing lasers, intense pulsed light, and photodynamic therapy. Soft tissue atrophy can be corrected with autologous fat, nonanimal stabilized hyaluronic acid, calcium hydroxylapatite, and poly-L lactic acid injections. The literature shows that these treatments have favorable outcomes for most patients; but in order to reduce known complications, it is important to understand the proper use and limitations of each modality.
Semin Cutan Med Surg 34:147-152 © 2015 Frontline Medical Communications

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