Skin Imaging With Reflectance Confocal Microscopy

Confocal microscopy is a new imaging modality for noninvasive real-time tissue imaging
with high resolution and contrast comparable with conventional histology. Application of
this technology to skin imaging during the last decade has been an exciting advance in
dermatology, allowing a virtual widow into living skin without the need for a conventional
biopsy or histologic processing of tissue. High-resolution noninvasive skin imaging with
confocal microscopy has potential broad applications in the clinical and research arenas,
including differentiating between benign and malignant skin lesions, tumor margin mapping,
monitoring response to medical or surgical treatments, and pathophysiologic study of
inflammatory processes.
Semin Cutan Med Surg 27:37-43 © 2008 Elsevier Inc. All rights reserved.

Confocal microscopy is a new imaging modality for noninvasive real-time tissue imaging
with high resolution and contrast comparable with conventional histology. Application of
this technology to skin imaging during the last decade has been an exciting advance in
dermatology, allowing a virtual widow into living skin without the need for a conventional
biopsy or histologic processing of tissue. High-resolution noninvasive skin imaging with
confocal microscopy has potential broad applications in the clinical and research arenas,
including differentiating between benign and malignant skin lesions, tumor margin mapping,
monitoring response to medical or surgical treatments, and pathophysiologic study of
inflammatory processes.
Semin Cutan Med Surg 27:37-43 © 2008 Elsevier Inc. All rights reserved.

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