Ustekinumab for the treatment of psoriasis: an evidence update

USING TARGETED THERAPIES FOR INFLAMMATORY DERMATOSES

Ustekinumab for the treatment of psoriasis: an evidence update

Sep
2018
Vol. 37. No. 3
Zenas Z N Yiu, MBChB, BSc, MRCP | Richard B. Warren, PhD, MRCP

Ustekinumab is an interleukin-12/23 inhibitor used for the treatment of moderate-to-severe psoriasis. Here, we review new evidence since ustekinumab was licensed for relative efficacy in comparison with other biologic therapies from head-to-head randomized controlled trials and network meta-analyses for the treatment of psoriasis. We also review observational data emerging from psoriasis registries reporting the effectiveness and safety of ustekinumab. Overall, new evidence suggests that ustekinumab has a favorable balance between efficacy/effectiveness, safety, and tolerability and should remain a first-line biologic therapy option for patients with severe psoriasis at present.

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